What are 3 diseases that affect the spleen?

Splenomegaly, characterized by an enlarged spleen, can stem from diverse causes like infections (such as mononucleosis or malaria), liver ailments (like cirrhosis), blood disorders (like sickle cell anaemia), or specific cancers. Symptoms might not always manifest, but when severe, they can include abdominal pain, early satiety, or increased susceptibility to bleeding. 

Trauma to the abdomen can lead to a spleen rupture, an urgent medical issue causing internal bleeding. Hematologic disorders, such as thalassemia, sickle cell disease, or leukemia, can trigger spleen enlargement as it works overtime to clear abnormal blood cells. This expansion can result in anemia, fatigue, or abdominal discomfort. Seeking medical advice for diagnosis and tailored treatment is crucial when dealing with spleen-related concerns.